I’m glad this is being talked about. It’s painfully obvious that women have double the risk of men – I see this every time I’m called out to a memory care unit to do psychiatric assessments: 2/3 of the residents are female. I would argue that sub-optimal hormones are overwhelmingly the main reason, with all those other factors falling under hormones. The math is quite simple: Women that optimize Testosterone, Progesterone, and Estrogen after menopause (and continue to do so for the rest of their life) have roughly the same risk of Alzheimer’s as men. They also live several years longer and have significantly longer health span and 30 – 50% lower incidence of cardiovascular disease, compared with women who avoid hormone replacement therapy.